바이오리더스

Core source technology utilizing γ-PGA, which enhances the activation of natural killer cells by using a high-molecular substance created by a microorganism called "Bacillus subtilis" to stimulate immunocytes in the intestinal mucosal membrane.

New medicine development platform technology based on the immunoregulatory effects of a natural amino acid high-molecular refined substance, "γ-PGA (Poly-γ-glutamic Acid)"

• A structure in which glutamic acid, a necessary type of amino acid, is repetitively connected through gamma-peptide bonds
• Its mechanism is an immunoregulatory effect : TLR4 as a medium ① Induces innate immunity ② Strengthens adaptive immunity ③ Improves the tumor microenvironment (TEM) in a favorable manner

"Bacillus subtilis Chungkookjang," a GRAS (Generally recognized as safe) microorganism

• Produced with a patented strain

Medicine under development and diseases to be treated

LSIL medicine (BLS-H01): Clinical Phase 3 in progress

• Extended application for more diseases : A combined treatment of tumor with Immune Checkpoint Blockade (ICB), cell therapy products, etc.

Poly-γ-glutamic acid (γ-PGA)

• An edible amino acid, high-molecular material, and a natural substance found in bean-fermented foods such as Korea's very own
  "cheonggukjang"
• Produced by Bacillus subtilis Chungkookjang, a type of GRAS (generally recognized as safe) microorganism with edible safety established
  (MOAlifeplus's patented strain)
• Though it is a natural substance, a mass production system for γ-PGA of high molecular weight (2,000 kDa on average) has been established
  through a fermentation and refinement processes (certified as one of Korea's Top 10 New Technologies)
• Increase in immunoreaction via γ-PGA, effective against cancer, viruses, and inflammation diseases
• γ-PGA also has several health-related functions including moisturization, acceleration of mineral absorption, and inhibited activation of
  the lyase of hyaluronic acid, which is a tissue component inside the body